FORMULATION AND IN-VITRO EVALUATION OF PRAVAL BHASMA TABLET

V. V. CHOPADE

Abstract


Praval bhasma is mostly available in powder dosage form. One of the major problems with this dosage
form is inaccuracy of dosage. Higher dose of Praval bhasma contain major amount of calcium carbonate
produce adverse effects. Therefore uncoated tablets of Praval bhasma were prepared by conventional
wet granulation method using starch (as paste), methyl cellulose and gelatin at 2 % concentration and
evaluated for in-vitro parameters both official and non-official, viz. weight variation, friability, hardness,
assay of calcium carbonate, disintegration time, dissolution study and drug interaction study. Results of
study revealed that all prepared tablets fulfilled the official (IP) standards for weight uniformity, hardness,
friability test, assay of calcium carbonate and disintegration tests was done. Based on dissolution
efficiency (DE 60) value order of performance of binders was starch (as paste)> methylcellulose > gelatin.
Analysis of variance (ANOVA) of DE 60 values followed by Dunnet t s t Test indicates (p < 0.001) that the
tablets formulated with different binders produces significant difference in dissolution profile. Dissolution
of Praval bhasma tablets obeys first order kinetics. The IR spectra of Praval bhasma in pure form
and prepared tablets were found to be identical, indicating no interaction of binders in prepared tablets


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DOI: http://dx.doi.org/10.22377/ajp.v1i1.748

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