Formulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement

Dr. Vilas G. Jamakandi

Abstract


Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Results and Discussion: The results of differential scanning calorimeter and Fourier transform infrared analysis confirmed that the excipients are compatible with the drug. The liquisolid tablets formulated with PEG400 at drug concentration 20% w/w is the best formulations among the other 10 batches of liquisolid tablet prepared, in terms of superior dissolution profile. LSC3 with R value 15 gave the maximum drug release. Short term accelerated stability study of optimized formulation (LSC3) of carvedilol was carried out at 40°C ± 2°C and at 75% ± 5% RH for 1 month. Conclusion: Immediate release tablet of carvedilol using liquisolid compacts technique was prepared and evaluated for the compatibility studies. No significant change or variation was observed in any parameters throughout the study.

Full Text:

PDF


DOI: http://dx.doi.org/10.22377/ajp.v10i03.772

Refbacks

  • There are currently no refbacks.