A floating pulsatile drug delivery system based on hollow calcium pectinate beads

V G Somani, S R Shahi, Y K Udavant, S C Atram, R Satpute, N M Shinde

Abstract


The objective of the present work is to envisage and develop hollow calcium pectinate beads for floating pulsatile release of aceclofenac intended for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The method used for the development of the beads was a simple process of acid-base reaction during ionotropic cross linking. The floating beads obtained were porous, hollow with a bulk density <1 and had an Ft50 of 14-24 h. The floating beads showed a two-phase release pattern with initial lag phase during floating in an acidic medium followed by rapid pulse in phosphate buffer. The approach indicates the use
of hollow calcium pectinate microparticles as a promising floating pulsatile drug delivery system for site- and time-specific release of drug acting as per chronotherapy of disease.


Full Text:

PDF

References


Kulkarni AR, Soppimath KS, Aminabhavi TM, Rudzinski WE. In vitro

release kinetics of cefadroxil, loaded sodium alginate interpenetrating

network beads. Eur J Pharm Biopharm 2001;51:127-33.

Hwagno J, Skinner GW, Harcu WW, Barnum PE. Pharmaceutical

application of naturally occurring water soluble polymer. Pharmaceutical

Science Technology Today 1998;1:254-61.

Soppimth KS, Kulkarni AR, Aminabhavi TM. Controlled release of

antihypertensive drug from the interpenetrating network poly (vinyl)

alcohol, guar gum hydrogel microspheres. J Biomater Sci Polym Ed

;11:27-43.

Aydin Z, Akbuga J. Preparation and evaluation of pectin beads.

International Journal of Pharmaceutics 1996;137:133-6.

Sriamornsak P, Thirawong N, Putkhachorn S. Morphology and buoyancy

entrapped calcium pectinate gel beads, American Association of

Pharmaceutical of oil Scientists. AAPS J 2004;6:E24.

Pillay V, Fassihi R. In vitro release modulation from cross linked pelletsfor site-specific drug delivery to the gastrointestinal tract I. Comparison of pH responsive drug release and associated kinetics. J Control Release 1999;59:229-42.

Murata Y, Sasaki N, Miyamoto S, Kawashima S. Use of floating alginate

gel beads for stomach specific drug delivery. Eur J Pharm Biopharm

;50:221-6.

Bussmer T, Dashevsky A, Bodmeier R. A pulsatile drug delivery system

based on rupturable coated hard gelatin capsule. J Control Release

;93:331-9.

Akihiko K, Minako K, Masayasu S, Sakurai Y. Pulsed dextran release from calcium-alginate gel beads. Journal Of Controlled Release 1997;45:21-9.

Lemmer B. Circadian Rhythms and drug delivery. Journal of Controlled

Release 1991;16:63-74.

Gonzalez-Rodryguez ML, Holgado MA, Sanchez-Lafuente C,

Rabasco AM, Fini A. Alginate/Chitosan particulate systems for sodium

diclofenac release. Int J Pharm 2002;232:225-34.

Jarosz PJ, Parrott EL. Comparison of granule strength and tablet

strength. J Pharm Sci 1982;72:530-5.

Choi BY, Park HJ, Hwang SJ, JB Park, Preparation of alginate beads

for floating drug delivery system: effects of CO2g as-forming agents.

International Journal of Pharmaceutics; 2002, 239, 81-91.




DOI: http://dx.doi.org/10.22377/ajp.v3i2.252

Refbacks

  • There are currently no refbacks.