Effect of hydrocolloid on the physicochemical properties of theophylline-loaded agar microspheres

Rajendra Kotadiya, Vishnu Patel, Hemangi Surti, Harsha Patel


Theophylline-loaded agar microspheres were prepared and the effect of hydrocolloid on the physicochemical properties of the microspheres was investigated. Microspheres were prepared by the w/o emulsion solvent evaporation technique. Microspheres were spherical and free flowing, with particle size in the range of 105-123 μm. It was found that as the concentrations of the polymer and the hydrocolloid increased, the percentage yield, percentage encapsulation and percentage drug content also increased. An in vitro dissolution study was conducted according to the USP method (USP XXII) using apparatus I for 8 h.The dissolution profile of the developed formulation was compared with the marketed product (Theo SR).
The similar results of prepared formulation (t50 = 211.78) and marketed product (t50 = 209.29) suggest sustained release
of the drug.

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Jalal I, Zmaily E, Najib N, Dissolution kinetics of commercially available

controlled-release theophylline preparations. Int J Pharm 1989;52:63-70.

Baveja SK, Range RKV, Singh A, Gombar VK. Release characteristics of

some bronchodilators from compressed hydrophilic polymeric matrices

and their correlation with molecular geometry. Int J Pharm 1988;41:55-62.

Shan-Yang L, Tzu-Lag L. Different Types of Direct Compressible Excipients Affecting the Release Behavior of Theophylline Controlled- eleaserTablets Containing Eudragit Resins. Drug Develop Ind Pharm


Ishrat N, Chowdhury J, Mia Mohammad D, Md. Selim R. Effect of

Electrolytes on Release of Diclofenac Sodium from Agarose Beads.

The Dhaka University Journal of Pharmaceutical Sciences, 4, 2005,

- 839 (Online version).

Mora PC, Baraldi PG. Democosmetic applications of polymeric

biomaterials. In: S. Dumitriu editor. Polymeric Biomaterials. 2nd ed.

Marcel Dekker; New York: 2002. p. 459.

Woo DH, Stabilization of the emulsion prepared with dietary fiber from

corn hull. Food Sci Biotechnol 2001;10:348.

Phillips GO. Acacia gum (Gum Arabic): A nutritional fibre; metabolism

and calorific value. Food Addit Contam 1998;15:251.

Ross AH, Eastwood MA, Brydon WG, Busuttil A, McKay LF. A study of

the effects of dietary gum arabic in the rat. Br J Nutr 1984;51:47.

Ross AH, Eastwood MA, Brydon WG, Anderson JR, Anderson DM. A study

of the effects of dietary gum arabic in humans. Am J Clin Nutr 1983;37:368.

DOI: http://dx.doi.org/10.22377/ajp.v3i2.254


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